Mehrban, N; Zhu, B; Tamagnin, F; Young, FI; Wasmuth, A; Hudson, KL; Thomson, AR; ... Woolfson, DN; + view all Mehrban, N; Zhu, B; Tamagnin, F; Young, FI; Wasmuth, A; Hudson, KL; Thomson, AR; Birchall, MA; Randall, AD; Song, B; Woolfson, DN; - view fewer (2015) Functionalized α-Helical Peptide Hydrogels for Neural Tissue Engineering. ACS Biomaterials Science & Engineering , 1 (6) pp. 431-439. 10.1021/acsbiomaterials.5b00051.

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Abstract

Trauma to the central and peripheral nervous systems often lead to serious morbidity. Current surgical methods for repairing or replacing such damage have limitations. Tissue engineering offers a potential alternative. Here we show that functionalized α-helical-peptide hydrogels can be used to induce attachment, migration, proliferation and differentiation of murine embryonic neural stem cells (NSCs). Specifically, compared with undecorated gels, those functionalized with Arg-Gly-Asp-Ser (RGDS) peptides increase the proliferative activity of NSCs; promote their directional migration; induce differentiation, with increased expression of microtubule-associated protein-2, and a low expression of glial fibrillary acidic protein; and lead to the formation of larger neurospheres. Electrophysiological measurements from NSCs grown in RGDS-decorated gels indicate developmental progress toward mature neuron-like behavior. Our data indicate that these functional peptide hydrogels may go some way toward overcoming the limitations of current approaches to nerve-tissue repair.

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