UCL Discovery Stage
UCL home » Library Services » Electronic resources » UCL Discovery Stage

Frequentist and Bayesian meta‐regression of health state utilities for multiple myeloma incorporating systematic review and analysis of individual patient data

Hatswell, AJ; Burns, D; Baio, G; Wadelin, F; (2019) Frequentist and Bayesian meta‐regression of health state utilities for multiple myeloma incorporating systematic review and analysis of individual patient data. Health Economics , 28 (5) pp. 653-665. 10.1002/hec.3871. Green open access

[thumbnail of Hatswell 2017-02-12_MM utility synthesis manuscript_V2-1-1 CLEAN.pdf]
Preview
Text
Hatswell 2017-02-12_MM utility synthesis manuscript_V2-1-1 CLEAN.pdf - Accepted Version

Download (409kB) | Preview

Abstract

This analysis presents the results of a systematic review for health state utilities in multiple myeloma, as well as analysis of over 9,000 observations taken from registry and trial data. The 27 values identified from 13 papers are then synthesised in a frequentist nonparametric bootstrap model and a Bayesian meta‐regression. Results were similar between the frequentist and Bayesian models with low utility on disease diagnosis (approximately 0.55), raising to approximately 0.65 on first line treatment and declining slightly with each subsequent line. Stem cell transplant was also found to be a significant predictor of health‐related quality of life in both individual patient data and meta‐regression, with an increased utility of approximately 0.06 across different models. The work presented demonstrates the feasibility of Bayesian methods for utility meta‐regression, whilst also presenting an internally consistent set of data from the analysis of registry data. To facilitate easy updating of the data and model, data extraction tables and model code are provided as Data S1. The main limitations of the model relate to the low number of studies available, particularly in highly pretreated patients.

Type: Article
Title: Frequentist and Bayesian meta‐regression of health state utilities for multiple myeloma incorporating systematic review and analysis of individual patient data
Location: England
Open access status: An open access version is available from UCL Discovery
DOI: 10.1002/hec.3871
Publisher version: https://doi.org/10.1002/hec.3871
Language: English
Additional information: This version is the author accepted manuscript. For information on re-use, please refer to the publisher’s terms and conditions.
Keywords: EQ‐5D, cost‐effectiveness, multiple myeloma, utility synthesis
UCL classification: UCL
UCL > Provost and Vice Provost Offices
UCL > Provost and Vice Provost Offices > UCL BEAMS
UCL > Provost and Vice Provost Offices > UCL BEAMS > Faculty of Maths and Physical Sciences
UCL > Provost and Vice Provost Offices > UCL BEAMS > Faculty of Maths and Physical Sciences > Dept of Statistical Science
URI: https://discovery-pp.ucl.ac.uk/id/eprint/10070256
Downloads since deposit
Loading...
25,666Downloads
Download activity - last month
Loading...
Download activity - last 12 months
Loading...
Downloads by country - last 12 months
Loading...

Archive Staff Only

View Item View Item