Isogai, Y;
Wu, Z;
Love, MI;
Ahn, MH-Y;
Bambah-Mukku, D;
Hua, V;
Farrell, K;
(2018)
Multisensory Logic of Infant-Directed Aggression by Males.
Cell
, 175
(7)
1827-1841.e17.
10.1016/j.cell.2018.11.032.
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Abstract
Newborn mice emit signals that promote parenting from mothers and fathers but trigger aggressive responses from virgin males. Although pup-directed attacks by males require vomeronasal function, the specific infant cues that elicit this behavior are unknown. We developed a behavioral paradigm based on reconstituted pup cues and showed that discrete infant morphological features combined with salivary chemosignals elicit robust male aggression. Seven vomeronasal receptors were identified based on infant-mediated activity, and the involvement of two receptors, Vmn2r65 and Vmn2r88, in infant-directed aggression was demonstrated by genetic deletion. Using the activation of these receptors as readouts for biochemical fractionation, we isolated two pheromonal compounds, the submandibular gland protein C and hemoglobins. Unexpectedly, none of the identified vomeronasal receptors and associated cues were specific to pups. Thus, infant-mediated aggression by virgin males relies on the recognition of pup's physical traits in addition to parental and infant chemical cues.
| Type: | Article |
|---|---|
| Title: | Multisensory Logic of Infant-Directed Aggression by Males |
| Open access status: | An open access version is available from UCL Discovery |
| DOI: | 10.1016/j.cell.2018.11.032 |
| Publisher version: | https://doi.org/10.1016/j.cell.2018.11.032 |
| Language: | English |
| Additional information: | This version is the author accepted manuscript. For information on re-use, please refer to the publisher’s terms and conditions. |
| Keywords: | aggression, chemosensory receptors, infanticide, infants, parenting, parents, pheromones, sensory detection, social behavior, vomeronasal |
| UCL classification: | UCL UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Life Sciences UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Life Sciences > Div of Biosciences UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Life Sciences > The Sainsbury Wellcome Centre |
| URI: | https://discovery-pp.ucl.ac.uk/id/eprint/10070374 |
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