Voroslakos, M;
Takeuchi, Y;
Brinyiczki, K;
Tamas, Z;
Oliva, A;
Fernandez-Ruiz, A;
Kozak, G;
... Berenyi, A; + view all
(2018)
Direct effects of transcranial electric stimulation on brain circuits in rats and humans.
Nature Communications
, 9
, Article 483. 10.1038/s41467-018-02928-3.
Preview |
Text
s41467-018-02928-3.pdf - Published Version Download (4MB) | Preview |
Abstract
Transcranial electric stimulation is a non-invasive tool that can influence brain activity; however, the parameters necessary to affect local circuits in vivo remain to be explored. Here, we report that in rodents and human cadaver brains, ~75% of scalp-applied currents are attenuated by soft tissue and skull. Using intracellular and extracellular recordings in rats, we find that at least 1 mV/mm voltage gradient is necessary to affect neuronal spiking and subthreshold currents. We designed an ‘intersectional short pulse’ stimulation method to inject sufficiently high current intensities into the brain, while keeping the charge density and sensation on the scalp surface relatively low. We verify the regional specificity of this novel method in rodents; in humans, we demonstrate how it affects the amplitude of simultaneously recorded EEG alpha waves. Our combined results establish that neuronal circuits are instantaneously affected by intensity currents that are higher than those used in conventional protocols.
| Type: | Article |
|---|---|
| Title: | Direct effects of transcranial electric stimulation on brain circuits in rats and humans |
| Open access status: | An open access version is available from UCL Discovery |
| DOI: | 10.1038/s41467-018-02928-3 |
| Publisher version: | http://doi.org/10.1038/s41467-018-02928-3 |
| Language: | English |
| Additional information: | Copyright © The Author(s) 2018. Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/ licenses/by/4.0/. |
| UCL classification: | UCL UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences |
| URI: | https://discovery-pp.ucl.ac.uk/id/eprint/10070653 |
Archive Staff Only
 |
View Item |
