Senzai, Y;
Fernandez-Ruiz, A;
Buzsaki, G;
(2019)
Layer-Specific Physiological Features and Interlaminar Interactions in the Primary Visual Cortex of the Mouse.
Neuron
, 101
(3)
500-513.e5.
10.1016/j.neuron.2018.12.009.
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Abstract
The relationship between mesoscopic local field potentials (LFPs) and single-neuron firing in the multi-layered neocortex is poorly understood. Simultaneous recordings from all layers in the primary visual cortex (V1) of the behaving mouse revealed functionally defined layers in V1. The depth of maximum spike power and sink-source distributions of LFPs provided consistent laminar landmarks across animals. Coherence of gamma oscillations (30–100 Hz) and spike-LFP coupling identified six physiological layers and further sublayers. Firing rates, burstiness, and other electrophysiological features of neurons displayed unique layer and brain state dependence. Spike transmission strength from layer 2/3 cells to layer 5 pyramidal cells and interneurons was stronger during waking compared with non-REM sleep but stronger during non-REM sleep among deep-layer excitatory neurons. A subset of deep-layer neurons was active exclusively in the DOWN state of non-REM sleep. These results bridge mesoscopic LFPs and single-neuron interactions with laminar structure in V1.
| Type: | Article |
|---|---|
| Title: | Layer-Specific Physiological Features and Interlaminar Interactions in the Primary Visual Cortex of the Mouse |
| Open access status: | An open access version is available from UCL Discovery |
| DOI: | 10.1016/j.neuron.2018.12.009 |
| Publisher version: | http://doi.org/10.1016/j.neuron.2018.12.009 |
| Language: | English |
| Additional information: | Copyright © 2019 The Authors. Published by Elsevier Inc. This is an open access article under the CC BY license (http://creativecommons.org/licenses/by/4.0/). |
| Keywords: | primary visual cortex, laminar recordings, cortical layers, cell type, oscillation, current source density, alpha rhythm, sleep, optogenetics |
| UCL classification: | UCL UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences |
| URI: | https://discovery-pp.ucl.ac.uk/id/eprint/10070656 |
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