Rothwell, J;
(2019)
Transcranial brain stimulation: Past and future.
[Review].
Brain and Neuroscience Advances
, 2
pp. 1-4.
10.1177/2398212818818070.
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Abstract
This article provides a brief summary of the history of transcranial methods for stimulating the human brain in conscious volunteers and reviews the methodology and physiology of transcranial magnetic stimulation and transcranial direct current stimulation. The former stimulates neural axons and generates action potentials and synaptic activity, whereas the latter polarises the membrane potential of neurones and changes their sensitivity to ongoing synaptic inputs. When coupled with brain imaging methods such as functional magnetic resonance imaging or electroencephalography, transcranial magnetic stimulation can be used to chart connectivity within the brain. In addition, because it induces artificial patterns of activity that interfere with ongoing information processing within a cortical area, it is frequently used in cognitive psychology to produce a short-lasting ‘virtual lesion’. Both transcranial magnetic stimulation and transcranial direct current stimulation can produce short-lasting changes in synaptic excitability and associated changes in behaviour that are presently the source of much research for their therapeutic potential.
| Type: | Article |
|---|---|
| Title: | Transcranial brain stimulation: Past and future |
| Open access status: | An open access version is available from UCL Discovery |
| DOI: | 10.1177/2398212818818070 |
| Publisher version: | https://doi.org/10.1177/2398212818818070 |
| Language: | English |
| Additional information: | This article is distributed under the terms of the Creative Commons Attribution-NonCommercial 4.0 License (http://www.creativecommons.org/licenses/by-nc/4.0/) which permits non-commercial use, reproduction and distribution of the work without further permission provided the original work is attributed as specified on the SAGE and Open Access pages (https://us.sagepub.com/en-us/nam/open-access-at-sage). |
| Keywords: | Transcranial magnetic stimulation, transcranial direct current stimulation, virtual lesion, synaptic plasticity |
| UCL classification: | UCL UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences > UCL Queen Square Institute of Neurology UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences > UCL Queen Square Institute of Neurology > Clinical and Movement Neurosciences |
| URI: | https://discovery-pp.ucl.ac.uk/id/eprint/10070751 |
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