Maillard, PV;
van der Veen, AG;
Poirier, EZ;
Reis E Sousa, C;
(2019)
Slicing and dicing viruses: antiviral RNA interference in mammals.
EMBO Journal
, 38
(6)
, Article e100941. 10.15252/embj.2018100941.
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Abstract
To protect against the harmful consequences of viral infections, organisms are equipped with sophisticated antiviral mechanisms, including cell-intrinsic means to restrict viral replication and propagation. Plant and invertebrate cells utilise mostly RNA interference (RNAi), an RNA-based mechanism, for cell-intrinsic immunity to viruses while vertebrates rely on the protein-based interferon (IFN)-driven innate immune system for the same purpose. The RNAi machinery is conserved in vertebrate cells, yet whether antiviral RNAi is still active in mammals and functionally relevant to mammalian antiviral defence is intensely debated. Here, we discuss cellular and viral factors that impact on antiviral RNAi and the contexts in which this system might be at play in mammalian resistance to viral infection.
| Type: | Article |
|---|---|
| Title: | Slicing and dicing viruses: antiviral RNA interference in mammals |
| Location: | England |
| Open access status: | An open access version is available from UCL Discovery |
| DOI: | 10.15252/embj.2018100941 |
| Publisher version: | https://doi.org/10.15252/embj.2018100941 |
| Language: | English |
| Additional information: | © 2019 The Authors. This is an open access article under the terms of the Creative Commons Attribution 4.0 License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited. http://creativecommons.org/licenses/by/4.0/ |
| Keywords: | Dicer, RNA interference, antiviral immunity, double‐stranded RNA, interferons |
| UCL classification: | UCL UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences |
| URI: | https://discovery-pp.ucl.ac.uk/id/eprint/10071066 |
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