Witts, E; Murray, A; (2019) Vestibulospinal contributions to mammalian locomotion. Current Opinion in Physiology , 8 pp. 56-62. 10.1016/j.cophys.2018.12.010.

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Abstract

The basic mammalian locomotor pattern is generated by spinal circuits which must maintain enough output flexibility to sustain locomotion in an ever-changing environment. Lateral vestibulospinal tract (LVST) neurons receive multimodal sensory feedback regarding ongoing movement, as well as input from the forebrain and cerebellum, and send dense projections to multiple areas of the spinal cord. Traditionally, LVST-neurons have been implicated in the generation of reflexes that maintain upright posture, but they may also have an underappreciated role in the generation of normal locomotor movements. Here, we review anatomical data regarding the inputs, projection pathways and spinal targets of LVST-neurons and discuss evidence from both animal and human studies around their potential role in the modification of locomotor patterns in mammals.

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