Franklin, TB;
Silva, BA;
Perova, Z;
Marrone, L;
Masferrer, ME;
Zhan, Y;
Kaplan, A;
... Gross, CT; + view all
(2017)
Prefrontal cortical control of a brainstem social behavior circuit.
Nature Neuroscience
, 20
(2)
pp. 260-270.
10.1038/nn.4470.
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Abstract
The prefrontal cortex helps adjust an organism's behavior to its environment. In particular, numerous studies have implicated the prefrontal cortex in the control of social behavior, but the neural circuits that mediate these effects remain unknown. Here we investigated behavioral adaptation to social defeat in mice and uncovered a critical contribution of neural projections from the medial prefrontal cortex to the dorsal periaqueductal gray, a brainstem area vital for defensive responses. Social defeat caused a weakening of functional connectivity between these two areas, and selective inhibition of these projections mimicked the behavioral effects of social defeat. These findings define a specific neural projection by which the prefrontal cortex can control and adapt social behavior.
| Type: | Article |
|---|---|
| Title: | Prefrontal cortical control of a brainstem social behavior circuit |
| Location: | United States |
| Open access status: | An open access version is available from UCL Discovery |
| DOI: | 10.1038/nn.4470 |
| Publisher version: | https://doi.org/10.1038/nn.4470 |
| Language: | English |
| Additional information: | This version is the author accepted manuscript. For information on re-use, please refer to the publisher’s terms and conditions. |
| UCL classification: | UCL UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Life Sciences UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Life Sciences > The Sainsbury Wellcome Centre |
| URI: | https://discovery-pp.ucl.ac.uk/id/eprint/10071756 |
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