Gage, MC;
(2019)
Measuring Apoptotic Cell Engulfment (Efferocytosis) Efficiency.
Methods in Molecular Biology
, 1951
pp. 143-152.
10.1007/978-1-4939-9130-3_11.
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Abstract
Efferocytosis is the process of recognizing and removing dead and dying cells, performed by a variety of phagocytic cells including macrophages. It has recently been shown that liver X receptor (LXR) signaling in macrophages regulates the expression of important efferocytosis receptors, bridging and signaling molecules. Here we describe a sensitive yet robust efferocytosis assay, optimized to measure bone marrow-derived macrophage (BMDM) apoptotic cell engulfment capability. This assay can be applied to genetically or pharmacologically altered BMDMs.
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