Sala Frigerio, C;
Wolfs, L;
Fattorelli, N;
Thrupp, N;
Voytyuk, I;
Schmidt, I;
Mancuso, R;
... De Strooper, B; + view all
(2019)
The Major Risk Factors for Alzheimer's Disease: Age, Sex, and Genes Modulate the Microglia Response to Aβ Plaques.
Cell Reports
, 27
(4)
pp. 1293-1306.
10.1016/j.celrep.2019.03.099.
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Abstract
show how microglia respond to amyloid-β, the Alzheimer's disease (AD)-causing factor. Their major response, the ARMs response, is enriched for AD risk genes, is abolished by Apoe deletion, develops faster in female mice, and is also part of normal aging. Thus, major AD risk factors converge on microglia.
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