Little, D;
Ketteler, R;
Gissen, P;
Devine, MJ;
(2019)
Using stem cell-derived neurons in drug screening for neurological diseases.
Neurobiology of Aging
, 78
pp. 130-141.
10.1016/j.neurobiolaging.2019.02.008.
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Abstract
Induced pluripotent stem cells and their derivatives have become an important tool for researching disease mechanisms. It is hoped that they could be used to discover new therapies by providing the most reliable and relevant human in vitro disease models for drug discovery. This review will summarize recent efforts to use stem cell-derived neurons for drug screening. We also explain the current hurdles to using these cells for high-throughput pharmaceutical screening and developments that may help overcome these hurdles. Finally, we critically discuss whether induced pluripotent stem cell-derived neurons will come to fruition as a model that is regularly used to screen for drugs to treat neurological diseases.
| Type: |
Article
|
| Title: |
Using stem cell-derived neurons in drug screening for neurological diseases |
| Open access status: |
An open access version is available from UCL Discovery |
| DOI: |
10.1016/j.neurobiolaging.2019.02.008 |
| Publisher version: |
https://doi.org/10.1016/j.neurobiolaging.2019.02.0... |
| Language: |
English |
| Additional information: |
This version is the author accepted manuscript. For information on re-use, please refer to the publisher’s terms and conditions. |
| Keywords: |
Alzheimer's disease, Drug discovery, Drug screening, Embryonic stem cells, High content screening, Huntington's disease, Induced pluripotent stem cells, Motor neuron disease, Neurodegeneration, Parkinson's disease |
| UCL classification: |
UCL
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences > UCL Queen Square Institute of Neurology
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences > UCL Queen Square Institute of Neurology > Clinical and Movement Neurosciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Life Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Life Sciences > Lab for Molecular Cell Bio MRC-UCL
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Population Health Sciences > UCL GOS Institute of Child Health
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Population Health Sciences > UCL GOS Institute of Child Health > Genetics and Genomic Medicine Dept |
| URI: |
https://discovery-pp.ucl.ac.uk/id/eprint/10073690 |
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