Clesham, K;
Dowse, R;
Samarasinghe, S;
(2018)
Upfront Matched Unrelated Donor Transplantation in Aplastic Anemia.
Hematology/Oncology Clinics of North America
, 32
(4)
pp. 619-628.
10.1016/j.hoc.2018.03.004.
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Abstract
Idiopathic severe aplastic anemia (SAA) is a rare condition, and hemopoietic stem cell transplantation (HSCT) remains the only curative therapy; HSCT is considered first-line treatment in patients less than 35 years old with SAA with a matched sibling donor (MSD); Current best practice is less clear in those without an MSD. Immunosuppressive therapy (IST) has traditionally been thought of as first-line treatment in those without an MSD; however, there remains a significant risk of relapse and clonal evolution; Outcomes following matched unrelated donor (MUD) HSCT in SAA have improved because of advances in the development of high-resolution HLA typing, developments in supportive care, and implementation of novel conditioning regimens; After careful discussion with the patient and parents, MUD HSCT could be considered first-line treatment in selected patients.
| Type: | Article |
|---|---|
| Title: | Upfront Matched Unrelated Donor Transplantation in Aplastic Anemia |
| Open access status: | An open access version is available from UCL Discovery |
| DOI: | 10.1016/j.hoc.2018.03.004 |
| Publisher version: | https://doi.org/10.1016/j.hoc.2018.03.004 |
| Language: | English |
| Additional information: | This version is the author accepted manuscript. For information on re-use, please refer to the publisher’s terms and conditions. |
| Keywords: | Aplastic anemia, Hemopoietic stem cell transplantation (HSCT), Matched sibling donor, Matched unrelated donor |
| UCL classification: | UCL UCL > Provost and Vice Provost Offices UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Population Health Sciences UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Population Health Sciences > UCL GOS Institute of Child Health |
| URI: | https://discovery-pp.ucl.ac.uk/id/eprint/10073884 |
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