Sobhy, S;
Rogozinska, E;
Khan, KS;
(2017)
Accuracy of on-site tests to detect anemia during prenatal care.
International Journal of Gynecology and Obstetrics
, 139
(2)
pp. 130-136.
10.1002/ijgo.12289.
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Abstract
BACKGROUND: Anemia is a substantial contributor to poor pregnancy outcomes in low- and middle-income countries. Access to laboratory facilities is limited; therefore, on-site testing warrants attention. OBJECTIVES: To determine the accuracy of on-site tests to detect anemia in pregnancy. SEARCH STRATEGY: MEDLINE, Embase, Scopus, CINAHL, and Web of Science were searched from inception until March 2016, with no language restrictions, using the terms "pregnancy," "an(a)emia," and "h(a)emoglobin." SELECTION CRITERIA: Studies that evaluated the diagnostic accuracy of on-site hemoglobin tests versus laboratory-based reference tests during pregnancy were included. DATA COLLECTION AND ANALYSIS: Study characteristics and true positive, true negative, false positive, and false negative rates were extracted. Sensitivity, specificity, likelihood ratios, and post-test probabilities were calculated. Anemia was defined as a hemoglobin level of less than 110 g/L. MAIN RESULTS: Ten studies (4239 participants) were assessed. Copper sulfate provided 97% sensitivity (95% confidence interval [CI] 88%-100%) and 71% specificity (95% CI 55%-85%); the Sahli method provided 86% sensitivity (95% CI 75%-94%) and 83% specificity (95% CI 68%-93%); and HemoCue provided 85% sensitivity (95% CI 79%-90%) and 80% specificity (95% CI 76%-83%). CONCLUSIONS: Some on-site tests are accurate and should be made widely available to improve detection of anemia in pregnancy.
| Type: | Article |
|---|---|
| Title: | Accuracy of on-site tests to detect anemia during prenatal care |
| Location: | United States |
| Open access status: | An open access version is available from UCL Discovery |
| DOI: | 10.1002/ijgo.12289 |
| Publisher version: | http://doi.org/10.1002/ijgo.12289 |
| Language: | English |
| Additional information: | This version is the author accepted manuscript. For information on re-use, please refer to the publisher’s terms and conditions. |
| Keywords: | Anemia, On-site tests, Point-of-care tests, Pregnancy, Prenatal care, Screening, Anemia, Developing Countries, Female, Humans, Point-of-Care Systems, Predictive Value of Tests, Pregnancy, Pregnancy Complications, Hematologic, Prenatal Care, Prenatal Diagnosis |
| UCL classification: | UCL UCL > Provost and Vice Provost Offices UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Population Health Sciences UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Population Health Sciences > Inst of Clinical Trials and Methodology UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Population Health Sciences > Inst of Clinical Trials and Methodology > MRC Clinical Trials Unit at UCL |
| URI: | https://discovery-pp.ucl.ac.uk/id/eprint/10074236 |
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