Palombo, M;
Nunes, D;
Alexander, D;
Zhang, H;
Shemesh, N;
(2019)
Histological validation of the brain cell body imaging with diffusion MRI at ultrahigh field.
In: Port, JD and Noll, DC, (eds.)
Proceedings of the 27th ISMRM Annual Meeting and Exhibition.
ISMRM (International Society for Magnetic Resonance in Medicine): Concord, CA, USA.
Preview |
Text
Abstract_1_Palombo.pdf - Accepted Version Download (3MB) | Preview |
Abstract
Biophysical modelling of diffusion-weighted MRI (DW-MRI) data can help to gain more insight into brain microstructure. However, models need to be validated. This work validates a recently-developed technique for non-invasive mapping of brain cell-body (soma) size/ density with DW-MRI, by using ultrahigh-field DW-MRI experiments and histology of mouse brain. Predictions from numerical simulations are experimentally confirmed and brain’s maps of MR-measured soma size/density are shown to correspond very well with histology. We provide differential contrasts between cell layers that are less expressed in tensor analyses, leading to novel complementary contrasts of the brain tissue. Limitations and future research directions are discussed.
| Type: | Proceedings paper |
|---|---|
| Title: | Histological validation of the brain cell body imaging with diffusion MRI at ultrahigh field |
| Event: | ISMRM 27th Annual Meeting and Exhibition, 11-16 May 2019, Montreal, QC, Canada |
| Open access status: | An open access version is available from UCL Discovery |
| Publisher version: | https://www.ismrm.org/19m/ |
| Language: | English |
| Additional information: | This version is the author accepted manuscript. For information on re-use, please refer to the publisher’s terms and conditions. |
| UCL classification: | UCL UCL > Provost and Vice Provost Offices > UCL BEAMS UCL > Provost and Vice Provost Offices > UCL BEAMS > Faculty of Engineering Science UCL > Provost and Vice Provost Offices > UCL BEAMS > Faculty of Engineering Science > Dept of Computer Science |
| URI: | https://discovery-pp.ucl.ac.uk/id/eprint/10074393 |
Archive Staff Only
 |
View Item |
