Golay, X;
Zaiss, M;
Anemone, A;
Goerke, S;
Longo, DL;
Herz, K;
Pohmann, R;
... Scheffler, K; + view all
(2019)
Quantification of hydroxyl exchange of D-Glucose at physiological conditions for optimization of glucoCEST MRI at 3 T, 7 T and 9.4 T.
NMR in Biomedicine
, 32
(9)
, Article e4113. 10.1002/nbm.4113.
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Abstract
Purpose: (i) Determination of individual glucose hydroxyl exchange rates at physiological conditions, (ii) using this information for numerical optimization of glucoCEST/CESL preparation. To give guidelines for in vivo glucoCEST/CESL measurement parameters at clinical and ultra-high field strengths. Methods: 5 glucose solution samples at different pH were measured at 14.1 T at various B1 power levels. Multi-B1-Z-spectra Bloch-McConnell fits at physiological pH were further improved by fitting of Z-spectra of 5 pH values simultaneously. Obtained exchange rates are used in a 6-pool Bloch-McConnell simulation including a tissue-like water pool and semi-solid MT pool with different CEST and CESL pre-saturation pulse trains. In vivo glucose injection experiments were performed in a tumor mouse model at 7T. Results/Discussion: Glucose Z-spectra could be fitted with 4 exchanging pools at 0.66 ppm, 1.28 ppm, 2.08 ppm and 2.88 ppm. Corresponding hydroxyl exchange rates could be determined at pH = 7.2, T = 37 °C, and 1X PBS. Simulation of saturation transfer for this glucose system in a grey matter-like and a tumor-like system revealed optimal pulses at different field strengths of 9.4 T, 7 T and 3 T. Different existing sequences and approaches are simulated and discussed. Found optima could be experimentally verified in an animal model at 7 T. Conclusion: For the determined fast exchange regime pre-saturation pulses in the spin-lock regime (long recover time, short yet strong saturation) were found to be optimal. This study gives an estimation for optimization of the glucoCEST signal in vivo on the basis of glucose exchange rate at physiological conditions.
| Type: | Article |
|---|---|
| Title: | Quantification of hydroxyl exchange of D-Glucose at physiological conditions for optimization of glucoCEST MRI at 3 T, 7 T and 9.4 T |
| Open access status: | An open access version is available from UCL Discovery |
| DOI: | 10.1002/nbm.4113 |
| Publisher version: | https://doi.org/10.1002/nbm.4113 |
| Language: | English |
| Additional information: | © 2019 The Authors. NMR in Biomedicine Published by John Wiley & Sons Ltd This is an open access article under the terms of the Creative Commons Attribution‐NonCommercial License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited and is not used for commercial purposes. |
| UCL classification: | UCL UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences > UCL Queen Square Institute of Neurology UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences > UCL Queen Square Institute of Neurology > Brain Repair and Rehabilitation |
| URI: | https://discovery-pp.ucl.ac.uk/id/eprint/10074615 |
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