Hammond, K;
Lewis, H;
Faruqui, N;
Russell, C;
Hoogenboom, BW;
Ryadnov, MG;
(2019)
Helminth Defense Molecules as Design Templates for Membrane Active Antibiotics.
ACS Infectious Diseases
10.1021/acsinfecdis.9b00157.
(In press).
Preview |
Text
Hoogenboom_Helminth Defense Molecules as Design Templates for Membrane Active Antibiotics_AAM.pdf - Accepted Version Download (2MB) | Preview |
Abstract
A design template for membrane active antibiotics against microbial and tumor cells is described. The template is an amino acid sequence that combines the properties of helminth defense molecules, which are not cytolytic, with the properties of host-defense peptides, which disrupt microbial membranes. Like helminth defense molecules, the template folds into an amphipathic helix in both mammalian host and microbial phospholipid membranes. Unlike these molecules, the template exhibits antimicrobial and anticancer properties that are comparable to those of antimicrobial and anticancer antibiotics. The selective antibiotic activity of the template builds upon a functional synergy between three distinctive faces of the helix, which is in contrast to two faces of membrane-disrupting amphipathic structures. This synergy enables the template to adapt pore formation mechanisms according to the nature of the target membrane, inducing the lysis of microbial and tumor cells.
| Type: | Article |
|---|---|
| Title: | Helminth Defense Molecules as Design Templates for Membrane Active Antibiotics |
| Location: | United States |
| Open access status: | An open access version is available from UCL Discovery |
| DOI: | 10.1021/acsinfecdis.9b00157 |
| Publisher version: | https://doi.org/10.1021/acsinfecdis.9b00157 |
| Language: | English |
| Additional information: | This version is the author accepted manuscript. For information on re-use, please refer to the publisher’s terms and conditions. |
| Keywords: | antibiotics, antimicrobial peptides, atomic force microscopy, helminth defense molecules, membrane pore formation, oncolytic agents |
| UCL classification: | UCL UCL > Provost and Vice Provost Offices > UCL BEAMS UCL > Provost and Vice Provost Offices > UCL BEAMS > Faculty of Maths and Physical Sciences UCL > Provost and Vice Provost Offices > UCL BEAMS > Faculty of Maths and Physical Sciences > Dept of Physics and Astronomy |
| URI: | https://discovery-pp.ucl.ac.uk/id/eprint/10075658 |
Archive Staff Only
 |
View Item |
