Amaral, AJR;
Pasparakis, G;
(2019)
Cell membrane engineering with synthetic materials: Applications in cell spheroids, cellular glues and microtissue formation.
Acta Biomaterialia
, 90
pp. 21-36.
10.1016/j.actbio.2019.04.013.
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Abstract
Biologically inspired materials with tunable bio- and physicochemical properties provide an essential framework to actively control and support cellular behavior. Cell membrane remodeling approaches benefit from the advances in polymer science and bioconjugation methods, which allow for the installation of un-/natural molecules and particles on the cells’ surface. Synthetically remodeled cells have superior properties and are under intense investigation in various therapeutic scenarios as cell delivery systems, bio-sensing platforms, injectable biomaterials and bioinks for 3D bioprinting applications. In this review article, recent advances in the field of cell surface remodeling via bio-chemical means and the potential biomedical applications of these emerging cell hybrids are discussed.
| Type: | Article |
|---|---|
| Title: | Cell membrane engineering with synthetic materials: Applications in cell spheroids, cellular glues and microtissue formation |
| Location: | England |
| Open access status: | An open access version is available from UCL Discovery |
| DOI: | 10.1016/j.actbio.2019.04.013 |
| Publisher version: | https://doi.org/10.1016/j.actbio.2019.04.013 |
| Language: | English |
| Additional information: | This version is the author accepted manuscript. For information on re-use, please refer to the publisher’s terms and conditions. |
| Keywords: | Cell membrane engineering, cell aggregation, spheroids, 3D cell culture, cellular glues |
| UCL classification: | UCL UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Life Sciences |
| URI: | https://discovery-pp.ucl.ac.uk/id/eprint/10076540 |
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