Olsen, RK;
Carr, VA;
Daugherty, AM;
La Joie, R;
Amaral, RSC;
Amunts, K;
Augustinack, JC;
... Wisse, LEM; + view all
(2019)
Progress update from the hippocampal subfields group.
Alzheimer's and Dementia: Diagnosis, Assessment and Disease Monitoring
, 11
pp. 439-449.
10.1016/j.dadm.2019.04.001.
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Abstract
Introduction: Heterogeneity of segmentation protocols for medial temporal lobe regions and hippocampal subfields on in vivo magnetic resonance imaging hinders the ability to integrate findings across studies. We aim to develop a harmonized protocol based on expert consensus and histological evidence. Methods: Our international working group, funded by the EU Joint Programme–Neurodegenerative Disease Research (JPND), is working toward the production of a reliable, validated, harmonized protocol for segmentation of medial temporal lobe regions. The working group uses a novel postmortem data set and online consensus procedures to ensure validity and facilitate adoption. Results: This progress report describes the initial results and milestones that we have achieved to date, including the development of a draft protocol and results from the initial reliability tests and consensus procedures. Discussion: A harmonized protocol will enable the standardization of segmentation methods across laboratories interested in medial temporal lobe research worldwide
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