Makaronidis, JM;
Batterham, RL;
(2019)
The role of gut hormones in the pathogenesis and management of obesity.
[Review].
Current Opinion in Physiology
, 12
pp. 1-11.
10.1016/j.cophys.2019.04.007.
Preview |
Text
Batterham COPhys 28March.pdf - Accepted Version Download (793kB) | Preview |
Abstract
The growing obesity epidemic is driving the need for development of novel, effective therapeutic strategies for obesity and its complications. Increasing our understanding of the processes controlling body weight is therefore imperative. Gut hormones have emerged as essential regulators of energy homeostasis. Dysregulation of gut hormone physiology is increasingly implicated in obesity pathogenesis and the compensatory biological responses driving weight regain following energy restriction. Furthermore, gut hormones are among key mediators of the weight loss following Rouxen-Y gastric bypass and sleeve gastrectomy, the bariatric procedures which remain the most effective treatment for severe obesity. Therapeutic strategies targeting gut hormones and their receptors are driving a new pharmacotherapy era and constitute the most promising approach to addressing the obesity epidemic.
Archive Staff Only
 |
View Item |
