Morin, C;
Rodríguez, E;
Blier, PU;
Fortin, S;
(2017)
Potential Application of Eicosapentaenoic Acid Monoacylglyceride in the Management of Colorectal Cancer.
Marine Drugs
, 15
(9)
, Article 283. 10.3390/md15090283.
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Abstract
BACKGROUND: There is increasing evidence that marine omega-3 oils are involved in the reduction of cancer risk and progression. However, the anticancer effect of omega-3 monoglyceride on colorectal cancer has yet to be assessed. The goal of this study was to evaluate the anti-cancer effects of eicosapentaenoic acid monoglyceride (MAG-EPA) in HCT116 colorectal carcinoma cells. METHODS: The effect of MAG-EPA was evaluated in vitro on HCT116 cells and in vivo on mouse model of HCT116 xenograft. RESULTS: Our data reveal that MAG-EPA decreased cell proliferation and induced apoptosis in HCT116 cells. In a xenograft mouse model, daily per os administration of MAG-EPA reduced tumor growth. Furthermore, MAG-EPA treatments decreased EGFR, VEGFR, and AKT activation pathways and reduced VEGF and HIF1α expression levels in tumors. CONCLUSION: MAG-EPA may promote apoptosis and inhibit growth of tumors by suppressing EGFR and VEGFR activation pathways. Altogether, these data provide new evidence regarding the mode of action of MAG-EPA in colorectal cancer cells.
| Type: | Article |
|---|---|
| Title: | Potential Application of Eicosapentaenoic Acid Monoacylglyceride in the Management of Colorectal Cancer |
| Location: | Switzerland |
| Open access status: | An open access version is available from UCL Discovery |
| DOI: | 10.3390/md15090283 |
| Publisher version: | http://doi.org/10.3390/md15090283 |
| Language: | English |
| Additional information: | © 2017 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/). |
| Keywords: | EGFR, EPA, HIF1α, VEGF, apoptosis, colorectal carcinoma, Adenocarcinoma, Animals, Antineoplastic Agents, Aquatic Organisms, Cell Proliferation, Colorectal Neoplasms, Eicosapentaenoic Acid, Female, HCT116 Cells, Humans, Inhibitory Concentration 50, Mice, Mice, Nude, Monoglycerides |
| UCL classification: | UCL UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Life Sciences UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Life Sciences > Div of Biosciences UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Life Sciences > Div of Biosciences > Genetics, Evolution and Environment |
| URI: | https://discovery-pp.ucl.ac.uk/id/eprint/10076850 |
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