Mayor, R;
(2019)
Cell fate decisions during development.
Science
, 364
(6444)
pp. 937-938.
10.1126/science.aax7917.
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Abstract
This revised vision for neural crest cell differentiation is consistent with what has been proposed for the differentiation of other cell types, such as those of the hematopoietic lineage (13). The first stable bifurcation identified in neural crest differentiation separates progenitors of the sensory lineage from those of autonomic and mesenchymal fates. This is followed by additional binary decisions that separate autonomic neuronal fate from mesenchymal differentiation. This contrasts with the current view in which a single precursor differentiates directly into specific cell types. In addition, Soldatov et al. show that many transcription factors considered as “master regulators” for specific lineages are not expressed at the time of the bifurcation to differentiate into these three lineages. This suggests that the activation of specific gene expression programs around the bifurcation point is triggered not by these master regulators, but by environmental conditions, such as chemical or mechanical cues (3, 14).
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