Schreiber, S;
Wilisch-Neumann, A;
Schreiber, F;
Assmann, A;
Scheumann, V;
Perosa, V;
Jandke, S;
... Werring, DJ; + view all
(2019)
The spectrum of age-related small vessel diseases: potential overlap and interactions of amyloid and non-amyloid vasculopathies.
Neuropathology and Applied Neurobiology
10.1111/nan.12576.
(In press).
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Abstract
Deep perforator arteriopathy (DPA) and cerebral amyloid angiopathy (CAA) are the commonest known cerebral small vessel diseases (CSVD), which cause ischaemic stroke, intracebral haemorrhage (ICH) and vascular cognitive impairment (VCI). While thus far mainly considered as separate entities, we here propose that DPA and CAA share similarities, overlap and interact, so that "pure" DPA or CAA are extremes along a continuum of age-related small vessel pathologies. We suggest blood-brain barrier (BBB) breakdown, endothelial damage and impaired perivascular β-amyloid (Aβ) drainage are hallmark common mechanisms connecting DPA and CAA. We also suggest a need for new biomarkers (e.g. high-resolution imaging) to deepen understanding of the complex relationships between DPA and CAA. This article is protected by copyright. All rights reserved.
| Type: | Article |
|---|---|
| Title: | The spectrum of age-related small vessel diseases: potential overlap and interactions of amyloid and non-amyloid vasculopathies |
| Location: | England |
| Open access status: | An open access version is available from UCL Discovery |
| DOI: | 10.1111/nan.12576 |
| Publisher version: | https://doi.org/10.1111/nan.12576 |
| Language: | English |
| Additional information: | Copyright © 2019 The Authors. Neuropathology and Applied Neurobiology published by John Wiley & Sons Ltd on behalf of British Neuropathological Society. This is an open access article under the terms of the Creative Commons Attribution‐NonCommercial License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited and is not used for commercial purposes. |
| Keywords: | Cerebral small vessel diseases, blood-brain barrier, cerebral amyloid angiopathy, cerebrospinal fluid, deep perforator arteriopathy, hypertensive arteriopathy, imaging, positron emission tomography, β-amyloid drainage |
| UCL classification: | UCL UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences > UCL Queen Square Institute of Neurology UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences > UCL Queen Square Institute of Neurology > Brain Repair and Rehabilitation |
| URI: | https://discovery-pp.ucl.ac.uk/id/eprint/10080378 |
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