Gu, T;
Ren, Z;
Li, X;
Huang, J;
Han, G;
(2019)
A flexible smart membrane consisting of GO composite fibres and upconversion MSNs for microRNA detection.
Chemical Communications
, 55
(62)
pp. 9104-9107.
10.1039/c9cc02907a.
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Abstract
We have developed a photoluminescent membrane for microRNA detection, consisting of chemically modified mesoporous silica nanoparticles (CaF2:Yb/Ho@MSNs) attached, via single stranded DNA probes, to flexible polyurethane fibres coated with graphene oxide (GO). By detecting the release of the luminescent nanoparticles resulting from complementary co-hybridization between target miRNA sequences and the DNA probe, accurate measurements of the miRNA concentration at high sensitivity levels can be obtained. The constructs therefore offer a route to rapid detection and the potential for early cancer diagnosis.
| Type: | Article |
|---|---|
| Title: | A flexible smart membrane consisting of GO composite fibres and upconversion MSNs for microRNA detection |
| Open access status: | An open access version is available from UCL Discovery |
| DOI: | 10.1039/c9cc02907a |
| Publisher version: | https://doi.org/10.1039/c9cc02907a |
| Language: | English |
| Additional information: | This version is the author accepted manuscript. For information on re-use, please refer to the publisher’s terms and conditions. |
| UCL classification: | UCL UCL > Provost and Vice Provost Offices > UCL BEAMS UCL > Provost and Vice Provost Offices > UCL BEAMS > Faculty of Engineering Science UCL > Provost and Vice Provost Offices > UCL BEAMS > Faculty of Engineering Science > Dept of Mechanical Engineering |
| URI: | https://discovery-pp.ucl.ac.uk/id/eprint/10081061 |
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