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A flexible smart membrane consisting of GO composite fibres and upconversion MSNs for microRNA detection

Gu, T; Ren, Z; Li, X; Huang, J; Han, G; (2019) A flexible smart membrane consisting of GO composite fibres and upconversion MSNs for microRNA detection. Chemical Communications , 55 (62) pp. 9104-9107. 10.1039/c9cc02907a. Green open access

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Abstract

We have developed a photoluminescent membrane for microRNA detection, consisting of chemically modified mesoporous silica nanoparticles (CaF2:Yb/Ho@MSNs) attached, via single stranded DNA probes, to flexible polyurethane fibres coated with graphene oxide (GO). By detecting the release of the luminescent nanoparticles resulting from complementary co-hybridization between target miRNA sequences and the DNA probe, accurate measurements of the miRNA concentration at high sensitivity levels can be obtained. The constructs therefore offer a route to rapid detection and the potential for early cancer diagnosis.

Type: Article
Title: A flexible smart membrane consisting of GO composite fibres and upconversion MSNs for microRNA detection
Open access status: An open access version is available from UCL Discovery
DOI: 10.1039/c9cc02907a
Publisher version: https://doi.org/10.1039/c9cc02907a
Language: English
Additional information: This version is the author accepted manuscript. For information on re-use, please refer to the publisher’s terms and conditions.
UCL classification: UCL
UCL > Provost and Vice Provost Offices > UCL BEAMS
UCL > Provost and Vice Provost Offices > UCL BEAMS > Faculty of Engineering Science
UCL > Provost and Vice Provost Offices > UCL BEAMS > Faculty of Engineering Science > Dept of Mechanical Engineering
URI: https://discovery-pp.ucl.ac.uk/id/eprint/10081061
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