Geeson, C; Wei, L; Franklin, BD; (2020) High-risk medicines associated with clinically relevant medication-related problems in United Kingdom hospitals: a prospective observational study. British Journal of Clinical Pharmacology , 86 (1) pp. 165-169. 10.1111/bcp.14119.

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Abstract

The aim of this prospective observational study was to establish associations between the use of high-risk medicine groups and the study outcome: occurrence of at least one moderate or severe preventable medication-related problem (MRP). Data on MRPs, high-risk medicines, and other potential risk factors were collected from adults on medical wards in two UK hospitals. Logistic regression modelling was used to determine relationships between high-risk medicines and the study outcome. Among 1,503 eligible admissions, six high-risk medicine groups were associated with the study outcome on univariable analysis; multivariable analysis found only systemic antimicrobials and epilepsy medicines to be independently associated with the outcome (adjusted odds ratio 1.44, 95% confidence interval 1.08-1.92 and adjusted odds ratio 1.61, 95% confidence interval 1.16-2.25 respectively). Identification of high-risk medicine groups has potential to permit targeting of patients at highest risk of avoidable medication-related harm, but multivariable analysis suggests risk is likely to be multifactorial.

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