Rugg-Gunn, F;
(2020)
The role of devices in managing risk.
Epilepsy & Behavior
, 103
(B)
, Article 106456. 10.1016/j.yebeh.2019.106456.
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Abstract
Over the last few years, there has been significant expansion of wearable technologies and devices into the health sector, including for conditions such as epilepsy. Although there is significant potential to benefit patients, there is a paucity of well-conducted scientific research in order to inform patients and healthcare providers of the most appropriate technology. In addition to either directly or indirectly identifying seizure activity, the ideal device should improve quality of life and reduce the risk of sudden unexpected death in epilepsy (SUDEP). Devices typically monitor a number of parameters including electroencephalographic (EEG), cardiac, and respiratory patterns and can detect movement, changes in skin conductance, and muscle activity. Multimodal devices are emerging with improved seizure detection rates and reduced false positive alarms. While convulsive seizures are reliably identified by most unimodal and multimodal devices, seizures associated with no, or minimal, movement are frequently undetected. The vast majority of current devices detect but do not actively intervene. At best, therefore, they indicate the presence of seizure activity in order to accurately ascertain true seizure frequency or facilitate intervention by others, which may, nevertheless, impact the rate of SUDEP. Future devices are likely to both detect and intervene within an autonomous closed-loop system tailored to the individual and by self-learning from the analysis of patient-specific parameters. The formulation of standards for regulatory bodies to validate seizure detection devices is also of paramount importance in order to confidently ascertain the performance of a device; and this will be facilitated by the creation of a large, open database containing multimodal annotated data in order to test device algorithms. This paper is for the Special Issue: Prevent 21: SUDEP Summit - Time to Listen.
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