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Mechanisms of Müller glial cell morphogenesis

MacDonald, RB; Charlton-Perkins, M; Harris, WA; (2017) Mechanisms of Müller glial cell morphogenesis. Current Opinion in Neurobiology , 47 pp. 31-37. 10.1016/j.conb.2017.08.005. Green open access

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Abstract

Müller Glia (MG), the radial glia cells of the retina, have spectacular morphologies subserving their enormous functional complexity. As early as 1892, the great neuroanatomist Santiago Ramon y Cajal studied the morphological development of MG, defining several steps in their morphogenesis [1, 2]. However, the molecular cues controlling these developmental steps remain poorly understood. As MG have roles to play in every cellular and plexiform layer, this review discusses our current understanding on how MG morphology may be linked to their function, including the developmental mechanisms involved in MG patterning and morphogenesis. Uncovering the mechanisms governing glial morphogenesis, using transcriptomics and imaging, may provide shed new light on the pathophysiology and treatment of human neurological disorders.

Type: Article
Title: Mechanisms of Müller glial cell morphogenesis
Open access status: An open access version is available from UCL Discovery
DOI: 10.1016/j.conb.2017.08.005
Publisher version: https://doi.org/10.1016/j.conb.2017.08.005
Language: English
Additional information: This version is the author accepted manuscript. For information on re-use, please refer to the publisher’s terms and conditions.
UCL classification: UCL
UCL > Provost and Vice Provost Offices
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences > Institute of Ophthalmology
URI: https://discovery-pp.ucl.ac.uk/id/eprint/10085774
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