Smith, M;
(2016)
Therapeutic hypothermia and acute brain injury.
Anaesthesia and Intensive Care Medicine
, 17
(12)
pp. 602-606.
10.1016/j.mpaic.2016.09.014.
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Abstract
The neuroprotective effects of therapeutic cooling of the brain have been recognized for decades, but these have generally failed to translate into improved outcomes in clinical studies. Targeted temperature management (TTM) has established roles in the management of post-cardiac arrest syndrome and neonatal hypoxic-ischaemic encephalopathy, but its role in other brain injury types remains controversial. It is a therapeutic option in the management of intracranial hypertension, and fever control after brain injury. Many questions remain regarding the logistics of cooling (including length of treatment), and how best to manage complications of therapy, particularly shivering. This article will review the putative mechanisms of hypothermia-induced neuroprotection, the technical considerations for the clinician wishing to use TTM, and review the evidence for the clinical application of TTM after acute brain injury.
| Type: | Article |
|---|---|
| Title: | Therapeutic hypothermia and acute brain injury |
| Open access status: | An open access version is available from UCL Discovery |
| DOI: | 10.1016/j.mpaic.2016.09.014 |
| Publisher version: | https://doi.org/10.1016/j.mpaic.2016.09.014 |
| Language: | English |
| Additional information: | This version is the author accepted manuscript. For information on re-use, please refer to the publisher’s terms and conditions. |
| Keywords: | Acute ischaemic stroke, hypoxic-ischaemic encephalopathy, induced normothermia, intracerebral haemorrhage, intracranial pressure, subarachnoid haemorrhage,targeted temperature management, therapeutic hypothermia, traumatic brain injury |
| UCL classification: | UCL UCL > Provost and Vice Provost Offices > UCL BEAMS UCL > Provost and Vice Provost Offices > UCL BEAMS > Faculty of Engineering Science UCL > Provost and Vice Provost Offices > UCL BEAMS > Faculty of Engineering Science > Dept of Med Phys and Biomedical Eng |
| URI: | https://discovery-pp.ucl.ac.uk/id/eprint/10086148 |
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