Reuber, M;
Blackburn, DJ;
Elsey, C;
Wakefield, S;
Ardern, KA;
Harkness, K;
Venneri, A;
... Drew, P; + view all
(2018)
An Interactional Profile to Assist the Differential Diagnosis of Neurodegenerative and Functional Memory Disorders.
Alzheimer Disease & Associated Disorders
, 32
(3)
pp. 197-206.
10.1097/WAD.0000000000000231.
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Abstract
OBJECTIVE: Specialist services for dementia are seeing an increasing number of patients. We investigated whether interactional and linguistic features in the communication behavior of patients with memory problems could help distinguish between those with problems secondary to neurological disorders (ND) and those with functional memory disorder (FMD). METHODS: In part 1 of this study, a diagnostic scoring aid (DSA) was developed encouraging linguists to provide quantitative ratings for 14 interactional features. An optimal cut-off differentiating ND and FMD was established by applying the DSA to 30 initial patient-doctor memory clinic encounters. In part 2, the DSA was tested prospectively in 10 additional cases analyzed independently by 2 conversation analysts blinded to medical information. RESULTS: In part 1, the median score of the DSA was +5 in ND and -5 in FMD (P<0.001). The optimal numeric DSA cut-off (+1) identified patients with ND with a sensitivity of 86.7% and a specificity of 100%. In part 2, DSA scores of rater 1 correctly predicted 10/10 and those of rater 2 predicted 9/10 diagnoses. CONCLUSIONS: This study indicates that interactional and linguistic features can help distinguish between patients developing dementia and those with FMD and could aid the stratification of patients with memory problems.
| Type: | Article |
|---|---|
| Title: | An Interactional Profile to Assist the Differential Diagnosis of Neurodegenerative and Functional Memory Disorders |
| Location: | United States |
| Open access status: | An open access version is available from UCL Discovery |
| DOI: | 10.1097/WAD.0000000000000231 |
| Publisher version: | https://doi.org/10.1097/WAD.0000000000000231 |
| Language: | English |
| Additional information: | This version is the author accepted manuscript. For information on re-use, please refer to the publisher’s terms and conditions. |
| Keywords: | Dementia, Diagnosis, Differential, Female, Humans, Male, Memory Disorders, Middle Aged, Nervous System Diseases, Neuropsychological Tests, Surveys and Questionnaires |
| UCL classification: | UCL UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Population Health Sciences > UCL EGA Institute for Womens Health UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Population Health Sciences > UCL EGA Institute for Womens Health > Neonatology |
| URI: | https://discovery-pp.ucl.ac.uk/id/eprint/10086200 |
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