Mack, AR;
Barnes, MD;
Taracila, MA;
Hujer, AM;
Hujer, KM;
Cabot, G;
Feldgarden, M;
... Bonomo, RA; + view all
(2019)
A standard numbering scheme for class C β-lactamases.
Antimicrobial Agents and Chemotherapy
10.1128/AAC.01841-19.
(In press).
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Abstract
Unlike classes A and B, a standardized amino acid numbering scheme has not been proposed for the class C (AmpC) β-lactamases, which complicates communication in the field. Here, we propose a scheme developed through a collaborative approach that considers both sequence and structure, preserves traditional numbering of catalytically important residues (Ser64, Lys67, Tyr150, and Lys315), is adaptable to new variants or enzymes yet to be discovered, and includes a variation for genetic and epidemiological applications.
| Type: | Article |
|---|---|
| Title: | A standard numbering scheme for class C β-lactamases |
| Location: | United States |
| Open access status: | An open access version is available from UCL Discovery |
| DOI: | 10.1128/AAC.01841-19 |
| Publisher version: | https://doi.org/10.1128/AAC.01841-19 |
| Language: | English |
| Additional information: | This version is the author accepted manuscript. For information on re-use, please refer to the publisher’s terms and conditions. |
| UCL classification: | UCL UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Life Sciences UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Life Sciences > UCL School of Pharmacy UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Life Sciences > UCL School of Pharmacy > Pharma and Bio Chemistry |
| URI: | https://discovery-pp.ucl.ac.uk/id/eprint/10086472 |
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