Duhig, KE;
Seed, PT;
Myers, JE;
Bahl, R;
Bambridge, G;
Barnfield, S;
Ficquet, J;
... Hunter, RM; + view all
(2019)
Placental growth factor testing for suspected pre-eclampsia: a cost-effectiveness analysis.
BJOG: An International Journal of Obstetrics and Gynaecology
, 126
(11)
pp. 1390-1398.
10.1111/1471-0528.15855.
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Abstract
Objective To calculate the cost‐effectiveness of implementing PlGF testing alongside a clinical management algorithm in maternity services in the UK, compared with current standard care. Design Cost‐effectiveness analysis. Setting Eleven maternity units participating in the PARROT stepped‐wedge cluster‐randomised controlled trial. Population Women presenting with suspected pre‐eclampsia between 20+0 and 36+6 weeks’ gestation. Methods Monte Carlo simulation utilising resource use data and maternal adverse outcomes. Main outcome measures Cost per maternal adverse outcome prevented. Results Clinical care with PlGF testing costs less than current standard practice and resulted in fewer maternal adverse outcomes. There is a total cost‐saving of UK£149 per patient tested, when including the cost of the test. This represents a potential cost‐saving of UK£2,891,196 each year across the NHS in England. Conclusions Clinical care with PlGF testing is associated with the potential for cost‐savings per participant tested when compared with current practice via a reduction in outpatient attendances, and improves maternal outcomes. This economic analysis supports a role for implementation of PlGF testing in antenatal services for the assessment of women with suspected pre‐eclampsia.
| Type: | Article |
|---|---|
| Title: | Placental growth factor testing for suspected pre-eclampsia: a cost-effectiveness analysis |
| Open access status: | An open access version is available from UCL Discovery |
| DOI: | 10.1111/1471-0528.15855 |
| Publisher version: | https://doi.org/10.1111/1471-0528.15855 |
| Language: | English |
| Additional information: | This work is licensed under a Creative Commons Attribution 4.0 International License. The images or other third party material in this article are included in the Creative Commons license, unless indicated otherwise in the credit line; if the material is not included under the Creative Commons license, users will need to obtain permission from the license holder to reproduce the material. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/ |
| Keywords: | Science & Technology, Life Sciences & Biomedicine, Obstetrics & Gynecology, Economic analysis, placental growth factor, pre-eclampsia, SFLT-1/PLGF RATIO TEST, ECONOMIC-EVALUATION, URINE PROTEIN, PREDICTION, DIAGNOSIS, WOMEN |
| UCL classification: | UCL UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Population Health Sciences > Institute of Epidemiology and Health |
| URI: | https://discovery-pp.ucl.ac.uk/id/eprint/10086508 |
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