Yetisen, A;
Jiang, N;
Castenada Gonzales, C;
Erenoglu, Z;
Dong, J;
Dong, X;
Stosser, S;
... Cordeiro, M; + view all
(2019)
Scleral Lens Sensor for Ocular Electrolyte Analysis.
Advanced Materials
10.1002/adma.201906762.
(In press).
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Abstract
The quantitative analysis of tear analytes in point‐of‐care settings can enable early diagnosis of ocular diseases. Here, a fluorescent scleral lens sensor is developed to quantitatively measure physiological levels of pH, Na⁺, K⁺, Ca²⁺, Mg²⁺, and Zn²⁺ ions. Benzenedicarboxylic acid, a pH probe, displays a sensitivity of 0.12 pH units within pH 7.0–8.0. Crown ether derivatives exhibit selectivity to Na⁺ and K⁺ ions within detection ranges of 0–100 and 0–50 mmol L⁻¹, and selectivities of 15.6 and 8.1 mmol L⁻¹, respectively. A 1,2 bis(o‐aminophenoxy)ethane‐N,N,‐N',N'‐tetraacetic‐acid‐based probe allows Ca²⁺ ion sensing with 0.02–0.05 mmol L⁻¹ sensitivity within 0.50–1.25 mmol L⁻¹ detection range. 5‐Oxazolecarboxylic acid senses Mg²⁺ ions, exhibiting a sensitivity of 0.10–0.44 mmol L⁻¹ within the range of 0.5–0.8 mmol L⁻¹. The N‐(2‐methoxyphenyl)iminodiacetate Zn²⁺ ion sensor has a sensitivity of 1 µmol L⁻¹ within the range of 10–20 µmol L⁻¹. The fluorescent sensors are subsequently multiplexed in the concavities of an engraved scleral lens. A handheld ophthalmic readout device comprising light‐emitting diodes (LEDs) and bandpass filters is fabricated to excite as well as read the scleral sensor. A smartphone camera application and an user interface are developed to deliver quantitative measurements with data deconvolution. The ophthalmic system enables the assessment of dry eye severity stages and the differentiation of its subtypes.
| Type: | Article |
|---|---|
| Title: | Scleral Lens Sensor for Ocular Electrolyte Analysis |
| Open access status: | An open access version is available from UCL Discovery |
| DOI: | 10.1002/adma.201906762 |
| Publisher version: | https://doi.org/10.1002/adma.201906762 |
| Language: | English |
| Additional information: | © 2019 The Authors. Published by WILEY‐VCH Verlag GmbH & Co. KGaA, Weinheim. This is an open access article under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/). |
| Keywords: | biosensors, diagnostics, ophthalmology, scleral lenses, smartphones |
| UCL classification: | UCL UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences > Institute of Ophthalmology |
| URI: | https://discovery-pp.ucl.ac.uk/id/eprint/10088023 |
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