Zamparo, I;
Francia, S;
Franchi, SA;
Redolfi, N;
Costanzi, E;
Kerstens, A;
Fukutani, Y;
... Lodovichi, C; + view all
(2019)
Axonal Odorant Receptors Mediate Axon Targeting.
Cell Reports
, 29
(13)
4334-4348.e7.
10.1016/j.celrep.2019.11.099.
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Abstract
In mammals, odorant receptors not only detect odors but also define the target in the olfactory bulb, where sensory neurons project to give rise to the sensory map. The odorant receptor is expressed at the cilia, where it binds odorants, and at the axon terminal. The mechanism of activation and function of the odorant receptor at the axon terminal is, however, still unknown. Here, we identify phosphatidylethanolamine-binding protein 1 as a putative ligand that activates the odorant receptor at the axon terminal and affects the turning behavior of sensory axons. Genetic ablation of phosphatidylethanolamine-binding protein 1 in mice results in a strongly disturbed olfactory sensory map. Our data suggest that the odorant receptor at the axon terminal of olfactory neurons acts as an axon guidance cue that responds to molecules originating in the olfactory bulb. The dual function of the odorant receptor links specificity of odor perception and axon targeting.
| Type: | Article |
|---|---|
| Title: | Axonal Odorant Receptors Mediate Axon Targeting |
| Location: | United States |
| Open access status: | An open access version is available from UCL Discovery |
| DOI: | 10.1016/j.celrep.2019.11.099 |
| Publisher version: | https://doi.org/10.1016/j.celrep.2019.11.099 |
| Language: | English |
| Additional information: | © 2019 The Authors. This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/). |
| Keywords: | axon targeting, axonal odorant receptors, olfactory bulb, topographic map |
| UCL classification: | UCL UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences > UK Dementia Research Institute HQ |
| URI: | https://discovery-pp.ucl.ac.uk/id/eprint/10088785 |
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