Relax, Don't RAN Translate It

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Wilson, KM; Muralidharan, B; Isaacs, AM; (2019) Relax, Don't RAN Translate It. Neuron , 104 (5) pp. 827-829. 10.1016/j.neuron.2019.11.014. Green open access

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Abstract

The (GGGGCC)n repeat expansion in C9orf72, which is the most common cause of frontotemporal dementia and amyotrophic lateral sclerosis, is translated through repeat-associated non-AUG (RAN) translation. In this issue of Neuron, Cheng et al. (2019) report that the helicase DDX3X, which unwinds (or relaxes) RNA, suppresses RAN translation and toxicity.

Type:	Article
Title:	Relax, Don't RAN Translate It
Open access status:	An open access version is available from UCL Discovery
DOI:	10.1016/j.neuron.2019.11.014
Publisher version:	https://doi.org/10.1016/j.neuron.2019.11.014
Language:	English
Additional information:	This version is the author accepted manuscript. For information on re-use, please refer to the publisher’s terms and conditions.
Keywords:	Science & Technology, Life Sciences & Biomedicine, Neurosciences, Neurosciences & Neurology
UCL classification:	UCL UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences > UCL Queen Square Institute of Neurology UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences > UCL Queen Square Institute of Neurology > Neurodegenerative Diseases
URI:	https://discovery-pp.ucl.ac.uk/id/eprint/10090061

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