Talbot, S;
Doyle, B;
Huang, J;
Wang, J-C;
Ahmadi, M;
Roberson, DP;
Yekkirala, A;
... Woolf, CJ; + view all
(2020)
Vagal sensory neurons drive mucous cell metaplasia.
Journal of Allergy and Clinical Immunology
, 145
(6)
pp. 1693-1694.
10.1016/j.jaci.2020.01.003.
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Abstract
Summary: Airway sensory neuron-produced Substance P heightens allergy-induced goblet cell hyperplasia and hypersecretion of Muc5AC, electrically silencing these overreactive neurons reduced these components of lung type 2 allergic inflammatory response.
| Type: | Article |
|---|---|
| Title: | Vagal sensory neurons drive mucous cell metaplasia |
| Open access status: | An open access version is available from UCL Discovery |
| DOI: | 10.1016/j.jaci.2020.01.003 |
| Publisher version: | https://doi.org/10.1016/j.jaci.2020.01.003 |
| Language: | English |
| Additional information: | This version is the author accepted manuscript. For information on re-use, please refer to the publisher’s terms and conditions. |
| Keywords: | Vagal sensory neurons, TRPV1, QX-314, Optogenetic, Mucous metaplasia, Goblet cell hyperplasia, Substance P, Muc5AC, Muc5B, Asthma |
| UCL classification: | UCL UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences > Div of Medicine UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences > Div of Medicine > Wolfson Inst for Biomedical Research |
| URI: | https://discovery-pp.ucl.ac.uk/id/eprint/10090324 |
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