Wang, X;
Boffito, M;
Dickinson, L;
Bagkeris, E;
Khoo, S;
Post, FA;
Vera, J;
... POPPY Study, .; + view all
(2020)
Plasma NRTI concentration and their associations with liver and renal parameters in people living with HIV.
AIDS
, 34
(5)
pp. 790-793.
10.1097/QAD.0000000000002479.
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Abstract
Associations between markers of liver and renal dysfunction and NRTI plasma exposure are ill-defined. As part of a large cohort study (POPPY), we analysed associations between ALT and eGFR results in people living with HIV on tenofovir (TFV) disoproxil fumarate (TDF), emtricitabine (FTC), abacavir (ABC) and lamivudine (3TC). While we found no associations between NRTI concentrations and ALT, lower eGFR values were associated with greater TFV, FTC and 3TC exposure, whereas ABC showed no associations.
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