Watanabe, T;
Rees, G;
(2018)
Comparing the temporal relationship of structural and functional connectivity changes in different adult human brain networks: a single-case study [version 1; peer review: 1 approved, 1 approved with reservations].
Wellcome Open Research
, 3
, Article 50. 10.12688/wellcomeopenres.14572.1.
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Abstract
Background: Despite accumulated evidence for adult brain plasticity, the temporal relationships between large-scale functional and structural connectivity changes in human brain networks remain unclear. / Methods: By analysing a unique richly detailed 19-week longitudinal neuroimaging dataset, we tested whether macroscopic functional connectivity changes lead to the corresponding structural alterations in the adult human brain, and examined whether such time lags between functional and structural connectivity changes are affected by functional differences between different large-scale brain networks. / Results: In this single-case study, we report that, compared to attention-related networks, functional connectivity changes in default-mode, fronto-parietal, and sensory-related networks occurred in advance of modulations of the corresponding structural connectivity with significantly longer time lags. In particular, the longest time lags were observed in sensory-related networks. In contrast, such significant temporal differences in connectivity change were not seen in comparisons between anatomically categorised different brain areas, such as frontal and occipital lobes. These observations survived even after multiple validation analyses using different connectivity definitions or using parts of the datasets. / Conclusions: Although the current findings should be examined in independent datasets with different demographic background and by experimental manipulation, this single-case study indicates the possibility that plasticity of macroscopic brain networks could be affected by cognitive and perceptual functions implemented in the networks, and implies a hierarchy in the plasticity of functionally different brain systems.
| Type: | Article |
|---|---|
| Title: | Comparing the temporal relationship of structural and functional connectivity changes in different adult human brain networks: a single-case study [version 1; peer review: 1 approved, 1 approved with reservations] |
| Open access status: | An open access version is available from UCL Discovery |
| DOI: | 10.12688/wellcomeopenres.14572.1 |
| Publisher version: | https://doi.org/10.12688/wellcomeopenres.14572.1 |
| Language: | English |
| Additional information: | Copyright © 2018 Watanabe T and Rees G. This is an open access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. |
| Keywords: | neural plasticity, Hebb's rule, resting state, DTI |
| UCL classification: | UCL UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Life Sciences |
| URI: | https://discovery-pp.ucl.ac.uk/id/eprint/10091661 |
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