Vergalli, J;
Bodrenko, IV;
Masi, M;
Moynié, L;
Acosta-Gutiérrez, S;
Naismith, JH;
Davin-Regli, A;
... Pagès, J-M; + view all
(2020)
Porins and small-molecule translocation across the outer membrane of Gram-negative bacteria.
Nature Reviews Microbiology
, 18
(3)
pp. 164-176.
10.1038/s41579-019-0294-2.
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Acosta Gutierrez_Porins and small-molecule translocation across the outer membrane of Gram-negative bacteria_AAM.pdf - Accepted Version Download (1MB) | Preview |
Abstract
Gram-negative bacteria and their complex cell envelope, which comprises an outer membrane and an inner membrane, are an important and attractive system for studying the translocation of small molecules across biological membranes. In the outer membrane of Enterobacteriaceae, trimeric porins control the cellular uptake of small molecules, including nutrients and antibacterial agents. The relatively slow porin-mediated passive uptake across the outer membrane and active efflux via efflux pumps in the inner membrane creates a permeability barrier. The synergistic action of outer membrane permeability, efflux pump activities and enzymatic degradation efficiently reduces the intracellular concentrations of small molecules and contributes to the emergence of antibiotic resistance. In this Review, we discuss recent advances in our understanding of the molecular and functional roles of general porins in small-molecule translocation in Enterobacteriaceae and consider the crucial contribution of porins in antibiotic resistance.
| Type: | Article |
|---|---|
| Title: | Porins and small-molecule translocation across the outer membrane of Gram-negative bacteria |
| Location: | England |
| Open access status: | An open access version is available from UCL Discovery |
| DOI: | 10.1038/s41579-019-0294-2 |
| Publisher version: | https://doi.org/10.1038/s41579-019-0294-2 |
| Language: | English |
| Additional information: | This version is the author accepted manuscript. For information on re-use, please refer to the publisher’s terms and conditions. |
| Keywords: | Antibacterial drug resistance, Antimicrobial therapy, Bacterial structural biology, Bacterial translocation, Bacteriology, X-ray crystallography |
| UCL classification: | UCL UCL > Provost and Vice Provost Offices > UCL BEAMS UCL > Provost and Vice Provost Offices > UCL BEAMS > Faculty of Maths and Physical Sciences UCL > Provost and Vice Provost Offices > UCL BEAMS > Faculty of Maths and Physical Sciences > Dept of Chemistry |
| URI: | https://discovery-pp.ucl.ac.uk/id/eprint/10092508 |
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