Ozkahraman, B;
Emeriewen, K;
Saleh, GM;
Thanh, NTK;
(2020)
Engineering hydrogel nanoparticles to enhance transdermal local anaesthetic delivery in human eyelid skin.
RSC Advances
, 10
(7)
pp. 3926-3930.
10.1039/c9ra06712d.
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Abstract
Herein, we focused on developing the feasibility of nano-enabled local anaesthetic (LA) delivery to anaesthetise the full thickness of eyelid skin. For this purpose a temperature-responsive hydrogel poly(N-vinylcaprolactam-co-hyaluronic acid) (p(VCL-co-HA)) was prepared through aqueous emulsion polymerization with a Food and Drug Administration (FDA) approved p(VCL) and hyaluronic acid (HA) showing remarkably high LA drug loading capacity.
| Type: | Article |
|---|---|
| Title: | Engineering hydrogel nanoparticles to enhance transdermal local anaesthetic delivery in human eyelid skin |
| Open access status: | An open access version is available from UCL Discovery |
| DOI: | 10.1039/c9ra06712d |
| Publisher version: | https://doi.org/10.1039/C9RA06712D |
| Language: | English |
| Additional information: | © The Royal Society of Chemistry 2020. This article is licensed under a Creative Commons Attribution 3.0 Unported Licence (http://creativecommons.org/licenses/by/3.0/). |
| UCL classification: | UCL UCL > Provost and Vice Provost Offices UCL > Provost and Vice Provost Offices > UCL BEAMS UCL > Provost and Vice Provost Offices > UCL BEAMS > Faculty of Maths and Physical Sciences UCL > Provost and Vice Provost Offices > UCL BEAMS > Faculty of Maths and Physical Sciences > Dept of Physics and Astronomy |
| URI: | https://discovery-pp.ucl.ac.uk/id/eprint/10092789 |
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