Thomas, AM;
Brolih, S;
McGouran, JF;
El-Sagheer, AH;
Ptchelkine, D;
Jones, M;
McDonald, NQ;
... Brown, T; + view all
(2019)
Optimised oligonucleotide substrates to assay XPF-ERCC1 nuclease activity for the discovery of DNA repair inhibitors.
Chemical Communications
, 55
(78)
pp. 11671-11674.
10.1039/c9cc05476f.
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Abstract
We report the design and optimisation of novel oligonucleotide substrates for a sensitive fluorescence assay for high-throughput screening and functional studies of the DNA repair enzyme, XPF-ERCC1, with a view to accelerating inhibitor and drug discovery.
| Type: | Article |
|---|---|
| Title: | Optimised oligonucleotide substrates to assay XPF-ERCC1 nuclease activity for the discovery of DNA repair inhibitors |
| Open access status: | An open access version is available from UCL Discovery |
| DOI: | 10.1039/c9cc05476f |
| Publisher version: | https://doi.org/10.1039/c9cc05476f |
| Language: | English |
| Additional information: | This article is licensed under a Creative Commons Attribution 3.0 Unported Licence. http://creativecommons.org/licenses/by/3.0/ |
| UCL classification: | UCL UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Life Sciences |
| URI: | https://discovery-pp.ucl.ac.uk/id/eprint/10092936 |
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