Martinez Corrales, G;
Alic, N;
(2020)
Evolutionary conservation of transcription factors affecting longevity.
Trends in Genetics
, 36
(5)
pp. 373-382.
10.1016/j.tig.2020.02.003.
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Abstract
Gene expression can be optimised for health and longevity through manipulation of transcription factor (TF) activity. The effects of many such TFs are conserved between animal species indicating evolutionary conservation of underlying mechanisms. Lifespan-determining TFs regulate a plethora of cellular and organismal functions, including stress resistance, metabolism and growth. They interact with each other both within and between cells. Manipulating their activity in a single cell type can often be sufficient to insure longevity. The evolutionary conservation of their effects on ageing is most likely a reflection of the conservation of their function in processes, such as reproduction, growth, and metabolism, that are important earlier in life. Their effects on early and late life can, however, often be uncoupled.
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