Silvestre Patallo, I;
Subiel, A;
Westhorpe, A;
Gouldstone, C;
Tulk, A;
Sharma, RA;
Schettino, G;
(2020)
Development and Implementation of an End-To-End Test for Absolute Dose Verification of Small Animal Preclinical Irradiation Research Platforms.
International Journal of Radiation Oncology*Biology*Physics
, 107
(3)
pp. 587-596.
10.1016/j.ijrobp.2020.03.001.
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Abstract
OBJECTIVES Lack of standardization and inaccurate dosimetry assessment in pre-clinical research is hampering the translational opportunities for new radio-therapeutic interventions. The aim of this work was to develop and implement an end-to-end dosimetry test for small animal radiation research platforms to monitor and help improving accuracy of dose delivery and standardization across institutions. METHODS The test is based on a bespoke zoomorphic heterogeneous mouse and WT1 Petri dish phantoms with alanine as reference detector. Alanine measurements within the mouse phantom were validated with MC simulations at 0.5 mm Cu x-ray reference beam. Energy dependence of alanine in medium x-ray beam qualities was taken into consideration. For the end-to-end test, treatment plans considering tissue heterogeneities were created in Muriplan TPS and delivered to the phantoms at five Institutions using XXX small animal irradiation platforms. Mean calculated dose to the pellets were compared to alanine measured dose. RESULTS MC simulations and in phantom alanine measurements in XXX reference beam were in excellent agreement, validating the experimental approach. At one institute, initial measurements showed a larger than 12% difference between calculated and measured dose caused by incorrect input data. The physics data used by the calculation engine were corrected and the TPS was recommissioned. Subsequent end-to-end test measurements showed differences below 5%. With an anterior field, four of the participating institutes delivered dose to both phantoms within 5%. CONCLUSIONS An end-to-end dosimetry test was developed and implemented for dose evaluation in preclinical irradiations with small animal irradiation research platforms. The test was capable of detecting treatment planning commissioning errors and it highlighted critical elements in dose calculation. Absolute dosimetry with alanine in relevant pre-clinical irradiation conditions showed reasonable levels of accuracy when compared to TPS calculations. This work is providing an independent and traceable dosimetric validation in pre-clinical research involving small animal irradiations.
| Type: | Article |
|---|---|
| Title: | Development and Implementation of an End-To-End Test for Absolute Dose Verification of Small Animal Preclinical Irradiation Research Platforms |
| Location: | United States |
| Open access status: | An open access version is available from UCL Discovery |
| DOI: | 10.1016/j.ijrobp.2020.03.001 |
| Publisher version: | https://doi.org/10.1016/j.ijrobp.2020.03.001 |
| Language: | English |
| Additional information: | This version is the author accepted manuscript. For information on re-use, please refer to the publisher’s terms and conditions. |
| UCL classification: | UCL UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences > Cancer Institute |
| URI: | https://discovery-pp.ucl.ac.uk/id/eprint/10094050 |
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