Bruno, D;
Plaska, CR;
Clark, DPA;
Zetterberg, H;
Blennow, K;
Verbeek, MM;
Pomara, N;
(2021)
CSF α-synuclein correlates with CSF neurogranin in late-life depression.
International Journal of Neuroscience
, 131
(4)
pp. 357-361.
10.1080/00207454.2020.1744596.
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Abstract
PURPOSE/AIM OF THE STUDY: Major depressive disorder (MDD) in late life is linked to increased risk of subsequent dementia, but it is still unclear exactly what pathophysiological mechanisms underpin this link. A potential mechanism related to elevated risk of dementia in MDD is increased levels of α-synuclein (α-Syn), a protein found in presynaptic neuronal terminals. MATERIALS AND METHODS: In this study, we examined cerebrospinal fluid (CSF) levels of α-Syn in conjunction with biomarkers of neurodegeneration (amyloid-β 42, total and phospho tau) and synaptic dysfunction (neurogranin), and measures of memory ability, in 27 cognitively intact older individuals with MDD and 19 controls. RESULTS: Our results show that CSF α-Syn levels did not significantly differ across depressed and control participants, but α-Syn was directly associated with neurogranin levels, and indirectly linked to poorer memory ability. CONCLUSIONS: All in all, we found that α-Syn may be implicated in the association between late life MDD and synaptic dysfunction, although further research is needed to confirm these results.
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