Ioannou, F;
Dawi, MA;
Tetley, RJ;
Mao, Y;
Muñoz, JJ;
(2020)
Development of a New 3D Hybrid Model for Epithelia Morphogenesis.
Frontiers in Bioengineering and Biotechnology
, 8
, Article 405. 10.3389/fbioe.2020.00405.
Preview |
Text
fbioe-08-00405.pdf - Published Version Download (1MB) | Preview |
Abstract
Many epithelial developmental processes like cell migration and spreading, cell sorting, or T1 transitions can be described as planar deformations. As such, they can be studied using two-dimensional tools and vertex models that can properly predict collective dynamics. However, many other epithelial shape changes are characterized by out-of-plane mechanics and three-dimensional effects, such as bending, cell extrusion, delamination, or invagination. Furthermore, during planar cell dynamics or tissue repair in monolayers, spatial intercalation between the apical and basal sides has even been detected. Motivated by this lack of symmetry with respect to the midsurface, we here present a 3D hybrid model that allows us to model differential contractility at the apical, basal or lateral sides. We use the model to study the effects on wound closure of solely apical or lateral contractile contributions and show that an apical purse-string can be sufficient for full closure when it is accompanied by volume preservation.
| Type: | Article |
|---|---|
| Title: | Development of a New 3D Hybrid Model for Epithelia Morphogenesis |
| Location: | Switzerland |
| Open access status: | An open access version is available from UCL Discovery |
| DOI: | 10.3389/fbioe.2020.00405 |
| Publisher version: | https://doi.org/10.3389/fbioe.2020.00405 |
| Language: | English |
| Additional information: | Copyright © 2020 Ioannou, Dawi, Tetley, Mao and Muñoz. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY) (http://creativecommons.org/licenses/by/4.0/). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms. |
| Keywords: | modeling, morphogenesis, three dimensions, vertex, wound healing |
| UCL classification: | UCL UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Life Sciences UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Life Sciences > Lab for Molecular Cell Bio MRC-UCL |
| URI: | https://discovery-pp.ucl.ac.uk/id/eprint/10098984 |
Archive Staff Only
 |
View Item |
