Jons, D;
Zetterberg, H;
Malmeström, C;
Bergström, T;
Axelsson, M;
Blennow, K;
Thulin, M;
... Andersen, O; + view all
(2020)
Intrathecal immunoreactivity in people with or without previous infectious mononucleosis.
Acta Neurologica Scandinavica
, 142
(2)
pp. 161-168.
10.1111/ane.13280.
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Abstract
OBJECTIVES: The risk of developing multiple sclerosis (MS) increases (OR: 3.1) after infectious mononucleosis (IM). However, the nature of this link is obscure. We tested the hypothesis that IM might incur long-term sequelae, including low-key inflammatory activity, with characteristics of an MS endophenotype (or presymptomatic trait), and that assays of MS-relevant cyto-/chemokines in the cerebrospinal fluid (CSF) post IM may show a trend in this direction. MATERIALS AND METHODS: We selected seven CSF cytokines (IL-1b, IL-6, YKL-40, TNF-alpha) or chemokines (IL-8, CCL2, IP-10), representing pro-inflammatory factors previously associated with MS. We assayed the CSF levels of these seven cyto-/chemokines in healthy individuals with a median follow-up time of 10 years after serologically confirmed IM (post-IM group, n=22), and in healthy controls without a history of IM (n=19). A group of MS patients (n=23) were included as reference. RESULTS: The CSF levels of IP-10, YKL-40 and CCL-2 were higher in the post-IM group than in our IM unexposed controls (p = 0.021, 0.049, 0.028). Seven of seven cyto/chemokine assays showed a trend in the predicted direction (p of binomial ratio = 0.008). However, this trend was non-significant in a multivariate test (p = 0.22). A power analysis indicated that similar studies including a larger cohort would be numerically realistic. CONCLUSIONS: These results do not reject the hypothesis that the established epidemiological association between IM and MS results from a stepwise inflammatory propagation from IM sequele to an MS endophenotype (or presymptomatic trait) in a proportion of IM patients, pending confirmation with adequate power.
| Type: | Article |
|---|---|
| Title: | Intrathecal immunoreactivity in people with or without previous infectious mononucleosis |
| Location: | Denmark |
| Open access status: | An open access version is available from UCL Discovery |
| DOI: | 10.1111/ane.13280 |
| Publisher version: | http://dx.doi.org/10.1111/ane.13280 |
| Language: | English |
| Additional information: | This version is the author accepted manuscript. For information on re-use, please refer to the publisher’s terms and conditions. |
| Keywords: | Epstein-Barr virus, endophenotype, infectious mononucleosis, multiple sclerosis, presymtomatic |
| UCL classification: | UCL UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences > UCL Queen Square Institute of Neurology UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences > UCL Queen Square Institute of Neurology > Neurodegenerative Diseases |
| URI: | https://discovery-pp.ucl.ac.uk/id/eprint/10099103 |
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