Woodman, M;
Haeusler, IL;
Grandjean, L;
(2019)
Tuberculosis Genetic Epidemiology: A Latin American Perspective.
Genes
, 10
(1)
, Article 53. 10.3390/genes10010053.
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Abstract
There are an estimated 10 million new cases of tuberculosis worldwide annually, with 282,000 new or relapsed cases each year reported from the Americas. With improvements in genome sequencing technology, it is now possible to study the genetic diversity of tuberculosis with much greater resolution. Although tuberculosis bacteria do not engage in horizontal gene transfer, the genome is far more variable than previously thought. The study of genome-wide variation in tuberculosis has improved our understanding of the evolutionary origins of tuberculosis, the arrival of tuberculosis in Latin America, the genetic determinants of drug resistance, and lineage-specific associations with important clinical phenotypes. This article reviews what is known about the arrival of tuberculosis in Latin America, the genetic diversity of tuberculosis in Latin America, and the genotypic determinants of clinical phenotypes.
| Type: | Article |
|---|---|
| Title: | Tuberculosis Genetic Epidemiology: A Latin American Perspective |
| Open access status: | An open access version is available from UCL Discovery |
| DOI: | 10.3390/genes10010053 |
| Publisher version: | https://doi.org/10.3390/genes10010053 |
| Language: | English |
| Additional information: | This work is licensed under a Creative Commons Attribution 4.0 International License. The images or other third party material in this article are included in the Creative Commons license, unless indicated otherwise in the credit line; if the material is not included under the Creative Commons license, users will need to obtain permission from the license holder to reproduce the material. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/ |
| Keywords: | Science & Technology, Life Sciences & Biomedicine, Genetics & Heredity, Mycobacterium tuberculosis, tuberculosis, multidrug-resistant tuberculosis, Mycobacterium tuberculosis complex, genetics, whole-genome sequencing, South America, Latin America, pathology, transmission, RDRIO MYCOBACTERIUM-TUBERCULOSIS, MOLECULAR EPIDEMIOLOGY, POPULATION-STRUCTURE, DRUG-RESISTANCE, BEIJING STRAINS, CAPE-TOWN, IN-VITRO, MDR-TB, TRANSMISSION, LINEAGE |
| UCL classification: | UCL UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Population Health Sciences > UCL GOS Institute of Child Health UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Population Health Sciences > UCL GOS Institute of Child Health > Infection, Immunity and Inflammation Dept |
| URI: | https://discovery-pp.ucl.ac.uk/id/eprint/10100811 |
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