Bakos, B;
Szili, B;
Szabó, B;
Horváth, P;
Kirschner, G;
Kósa, JP;
Toldy, E;
... Takács, I; + view all
(2020)
Genetic variants of VDR and CYP2R1 affect BMI independently of serum vitamin D concentrations.
BMC Medical Genetics
, 21
, Article 129. 10.1186/s12881-020-01065-3.
Preview |
Text
BakosBBMCMedGenet2020.pdf - Published Version Download (551kB) | Preview |
Abstract
BACKGROUND: Vitamin D metabolism and obesity have been linked by several studies, however the reason for this association is unclear. Our objective was to investigate potential correlations between genetic variants in key enzymes of vitamin D metabolism and the body mass index on a representative and random sample of Hungarian adults. METHODS: Altogether 462 severely vitamin D deficient individuals were studied at the end of winter in order to decrease environmental and maximize any relevant genetic effect. Furthermore, participants with lifestyle factors known to affect vitamin D homeostasis were also excluded. We selected 23 target SNPs in five genes that encode key proteins of vitamin D metabolism (NADSYN1, GC, CYP24A1, CYP2R1, VDR). RESULTS: Variants in 2 genetic polymorphisms; rs2853564 (VDR) and rs11023374 (CYP2R1) showed a significant association with participants' BMI. These associations survived further adjustment for total-, free-, or bioactive-25(OH) vitamin D levels, although the variance explained by these 2 SNPS in BMI heterogeneity was only 3.2%. CONCLUSION: Our results show two novel examples of the relationship between genetics of vitamin D and BMI, highlighting the potential role of vitamin D hormone in the physiology of obesity.
| Type: | Article |
|---|---|
| Title: | Genetic variants of VDR and CYP2R1 affect BMI independently of serum vitamin D concentrations |
| Location: | England |
| Open access status: | An open access version is available from UCL Discovery |
| DOI: | 10.1186/s12881-020-01065-3 |
| Publisher version: | https://doi.org/10.1186/s12881-020-01065-3 |
| Language: | English |
| Additional information: | This is an open access article under the CC BY license (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. |
| Keywords: | BMI, CYP2R1, Genetics, VDR, Vitamin D |
| UCL classification: | UCL UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Population Health Sciences > Institute of Epidemiology and Health UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Population Health Sciences > Institute of Epidemiology and Health > Epidemiology and Public Health |
| URI: | https://discovery-pp.ucl.ac.uk/id/eprint/10101598 |
Archive Staff Only
 |
View Item |
