Cano, A;
Sánchez-López, E;
Ettcheto, M;
López-Machado, A;
Espina, M;
Souto, EB;
Galindo, R;
... Turowski, P; + view all
(2020)
Current advances in the development of novel polymeric nanoparticles for the treatment of neurodegenerative diseases.
Nanomedicine
, 15
(12)
pp. 1239-1261.
10.2217/nnm-2019-0443.
Preview |
Text
Cano_2020_Current advances in the development of novel polymeric nanoparticles for the treatment of neurodegenerative diseases.pdf - Accepted Version Download (2MB) | Preview |
Abstract
Effective intervention is essential to combat the coming epidemic of neurodegenerative (ND) diseases. Nanomedicine can overcome restrictions of CNS delivery imposed by the blood-brain barrier, and thus be instrumental in preclinical discovery and therapeutic intervention of ND diseases. Polymeric nanoparticles (PNPs) have shown great potential and versatility to encapsulate several compounds simultaneously in controlled drug-delivery systems and target them to the deepest brain regions. Here, we critically review recent advances in the development of drugs incorporated into PNPs and summarize the molecular changes and functional effects achieved in preclinical models of the most common ND disorders. We also briefly discuss the many challenges remaining to translate these findings and technological advances successfully to current clinical settings.
| Type: | Article |
|---|---|
| Title: | Current advances in the development of novel polymeric nanoparticles for the treatment of neurodegenerative diseases |
| Location: | England |
| Open access status: | An open access version is available from UCL Discovery |
| DOI: | 10.2217/nnm-2019-0443 |
| Publisher version: | https://doi.org/10.2217/nnm-2019-0443 |
| Language: | English |
| Additional information: | This version is the author accepted manuscript. For information on re-use, please refer to the publisher's terms and conditions. |
| Keywords: | CNS nanomedicine, brain disorders, brain targeting, neurodegenerative diseases, neurological diseases, polymeric nanoparticles |
| UCL classification: | UCL UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences > Institute of Ophthalmology |
| URI: | https://discovery-pp.ucl.ac.uk/id/eprint/10102214 |
Archive Staff Only
 |
View Item |
