Batchelor, Hannah;
(2001)
An investigation into the adhesion of alginate solutions in œsophageal tissue.
Doctoral thesis (Ph.D.), University College London (United Kingdom).
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Abstract
Bioadhesive devices have been investigated within the pharmaceutical industry for the past twenty years as a technique to enhance drug bioavailability from localised delivery formulations. Bioadhesive entities have previously been targeted at many sites within the body. This study investigated the feasibility of a liquid bioadhesive system targeted at œsophageal tissue. Such a system has implications in the treatment of gastro-œsophageal reflux disease and also as a novel means of localised drug delivery. Gastro-œsophageal reflux occurs when the acidic contents of the gastric material damage the œsophageal epithelium during reflux episodes. An adhesive alginate layer may enhance the protective systems present within the oesophagus and limit the damage caused by refluxate. Alginates are currently utilised in the management of gastro-œsophageal reflux disease and have also previously been shown to possess bioadhesive potential. This study investigated the interaction between alginate solutions and œsophageal tissue using techniques that allowed assessment on both a macro and microscopic scale. The presence of mucin within the unstirred water layer resident on the œsophageal tissue surface was determined and quantified. The concentration of mucin within the layer was found to be 0.3 % w/v. Rheological studies investigated the interaction between alginate and mucin as well as interactions between alginate and physiologically relevant biological substrates. Rheological synergy is indicative of an adhesive interaction. Synergy was observed in mixed systems of alginate and components of the unstirred water layer. The physico-chemical properties of the alginate were not found to influence the extent of synergy observed. The extent and duration of alginate adhesion on œsophageal tissue was assessed using two techniques; a retention model and microscopy. The results showed that alginate can adhere to œsophageal tissue for periods of at least 60 minutes. The physico-chemical properties of the alginate were not found to influence the retention of the alginate dose.
| Type: | Thesis (Doctoral) |
|---|---|
| Qualification: | Ph.D. |
| Title: | An investigation into the adhesion of alginate solutions in œsophageal tissue |
| Open access status: | An open access version is available from UCL Discovery |
| Language: | English |
| Additional information: | Thesis digitised by ProQuest. |
| Keywords: | (UMI)AAI10104712; Health and environmental sciences; Adhesion; Alginate; Oelig;sophageal; Tissue |
| URI: | https://discovery-pp.ucl.ac.uk/id/eprint/10102416 |
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