Lindström, J;
Bremell, D;
Grahn, A;
Blennow, K;
Zetterberg, H;
Studahl, M;
(2020)
CXCL13 in patients with facial palsy caused by varicella zoster virus and Borrelia burgdorferi: a comparative study.
Diagnostic Microbiology and Infectious Disease
, 98
(1)
10.1016/j.diagmicrobio.2020.115095.
(In press).
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Abstract
High cerebrospinal fluid (CSF) concentrations of the chemokine CXCL13 have been associated with Lyme neuroborreliosis (LNB), and have recently been studied as a potential diagnostic marker. It has proven difficult to establish a reliable diagnostic cut-off, possibly in part due to heterogenicity of case–control groups. Our purpose was to investigate CSF CXCL13 concentrations in patients with similar clinical presentations, facial palsy. We retrospectively included patients with facial palsy associated with LNB (n = 21), or varicella zoster virus (VZV) (n = 26). Median CXCL13 concentrations were significantly higher in patients with LNB facial palsy compared to VZV facial palsy. Receiver-operating characteristic analyses yielded an optimal cut-off concentration at 34.5 pg/mL (sensitivity 85.7%, specificity of 84.6%), lower than that in previous studies. Although the analysis has potential, it is still not adequately established that CXCL13 provides additional, clinically useful, diagnostic information over current recommendations.
| Type: | Article |
|---|---|
| Title: | CXCL13 in patients with facial palsy caused by varicella zoster virus and Borrelia burgdorferi: a comparative study |
| Open access status: | An open access version is available from UCL Discovery |
| DOI: | 10.1016/j.diagmicrobio.2020.115095 |
| Publisher version: | http://dx.doi.org/10.1016/j.diagmicrobio.2020.1150... |
| Language: | English |
| Additional information: | © 2020 The Authors. Published by Elsevier Inc. This is an open access article under the CC BY license (http:// creativecommons.org/licenses/by/4.0/). |
| Keywords: | CXCL13, Cerebrospinal fluid, Lyme neuroborreliosis, Facial paralysis, Varicella zoster virus |
| UCL classification: | UCL UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences > UCL Queen Square Institute of Neurology UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences > UCL Queen Square Institute of Neurology > Neurodegenerative Diseases |
| URI: | https://discovery-pp.ucl.ac.uk/id/eprint/10104163 |
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